Definition: A family of picornaviruses, included in the genus Enterovirus, of icosahedral shape, stable at acid pH, and about 28 nm in diameter, causing myositis, paralysis, and death in young mice, and responsible for a variety of diseases in humans, although inapparent infections are common. They are divided antigenically into two groups, A and B, each of which includes serologic types, Enterovirus coxsackie A1 to 24 and Enterovirus coxsackie B1 to 6. Type A viruses cause human herpangina and hand-foot-and-mouth disease; type B viruses cause epidemic pleurodynia; both type viruses may cause aseptic meningitis, myocarditis and pericarditis, and Type 1 diabetes.
[Coxsackie, N.Y., where first isolated]
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