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Pronunciation: kor'ti-son

Definition: 17-hydroxy-11-dehydrocorticosterone, a biologically inactive adrenal corticosteroid produced by the reversible 11-hydroxylation of cortisol (17-hydroxycorticosterone). It was the first glucocorticoid to be used in therapy (1949). Like the endogenous substance, natural and synthetic cortisone administered as a drug exerts no effect until converted to cortisol.

Synonym(s): Wintersteiner compound E

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© Copyright 2018 Wolters Kluwer. All Rights Reserved. Review Date: Sep 19, 2016.