Nuclear proteins that participate in the regulation of transcription of genes that are responsive to ligand-dependent transcription factors. Distinguished loosely into coactivators or corepressors depending on the direction of coregulation. Defective coregulators have been associated with human disease.
[co- + regulator]
See Also: coactivator, corepressors
Search Stedman's Medical Dictionary
Examples: glitazone, GI cocktail, etc.