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Medical Term:


Pronunciation: ko'reg'yu-la-torz

Definition: Nuclear proteins that participate in the regulation of transcription of genes that are responsive to ligand-dependent transcription factors. Distinguished loosely into coactivators or corepressors depending on the direction of coregulation. Defective coregulators have been associated with human disease.

[co- + regulator]

See Also: coactivator, corepressors

© Copyright 2016 Wolters Kluwer. All Rights Reserved. Review Date: Sep 19, 2016.