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Medical Term:


Pronunciation: kō-op′er-ă-tiv′i-tē

Definition: A property of certain proteins (often enzymes) in which the binding curves or saturation curves or, in the case of enzymes, a plot of initial rates as a function of initial substrate concentration, are nonhyperbolic; suggests that the binding of a ligand has a different affinity at different ligand concentrations. Both allosterism and hysteresis display cooperativity.