Definition: any internally administered substance that has a different opacity from soft tissue on radiography or computed tomography; includes barium, used to opacify parts of the gastrointestinal tract; water-soluble iodinated compounds, used to opacify blood vessels or the genitourinary tract; may refer to air occurring naturally or introduced into the body; also, paramagnetic substances used in magnetic resonance imaging.
Synonym(s): contrast agent, contrast material
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Examples: glitazone, GI cocktail, etc.
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