Definition: congenital dilation and hypertrophy of the colon due to absence (aganglionosis) or marked reduction (hypoganglionosis) in the number of ganglion cells of the myenteric plexus of the rectum and a varying but continuous length of gut above the rectum; seen in humans and dogs.
Synonym(s): Hirschsprung disease
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© Copyright 2018 Wolters Kluwer. All Rights Reserved. Review date: Sep 19, 2016.