Definition: The spatial arrangement of a molecule achieved by rotation of groups about single covalent bonds, without breaking any covalent bonds; the latter restriction differentiates conformation from configuration (as in anomers and related stereoisomers) where a bond or bonds must be broken in going from one form (configuration) to another. Conformation is one of the most important aspects of sugar chemistry and is basic to an understanding of the chemical properties of sugars.
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Examples: glitazone, GI cocktail, etc.