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complement fixation

 

Definition:

  1. antigen-antibody interactions cause a conformational shift in immunoglobulin structure promoting binding of C1 and subsequent activation of the complement cascade, complement fixation.
  2. an immunoassay using reference antibodies with complement fixation and lysis of red blood cells as an indicator of detectable antigen. The degree of hemolysis affects the optic density of the sample, which can be measured and compared with a standard reference concentration curve.

Synonym(s): CF test, complement binding assay

See Also: Bordet-Gengou phenomenon, Wassermann test

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© Copyright 2017 Wolters Kluwer. All Rights Reserved. Review Date: Sep 19, 2016.
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