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competitive inhibition


Definition: blocking of the action of an enzyme by a compound that binds to the free enzyme, preventing the substrate from binding and thus preventing the enzyme from acting on that substrate. The competitive inhibitor is often a substrate analogue and binds at the active site; however, this is not an absolute requirement for competitive inhibition. Saturating concentrations of substrate can remove the inhibition.

Synonym(s): selective inhibition

Further information

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© Copyright 2018 Wolters Kluwer. All Rights Reserved. Review date: Sep 19, 2016.