colorimetric in situ hybridization
automated paraffin-based method used to detect plasma-cell and B-cell immunoglobulin light-chain restriction in bone marrow biopsies, among others. Also analogous to fluorescence in situ hybridization for detection of HER-2 gene amplification.
Synonym(s): chromogenic in situ hybridization
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Examples: glitazone, GI cocktail, etc.