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colorimetric in situ hybridization


Definition: automated paraffin-based method used to detect plasma-cell and B-cell immunoglobulin light-chain restriction in bone marrow biopsies, among others. Also analogous to fluorescence in situ hybridization for detection of HER-2 gene amplification.

Synonym(s): chromogenic in situ hybridization

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© Copyright 2018 Wolters Kluwer. All Rights Reserved. Review Date: Sep 19, 2016.