Definition: an antibody that agglutinates particulate antigens (bacteria) at temperatures below 37°C, often most actively at 4°C; most are the IgM class of immunoglobulins with affinity for the Ii system of erythrocyte antigens, but some are anti-Pr cold autoagglutinins; cold autoagglutinins may be associated with infection (primary atypical pneumonia, infectious mononucleosis and other virus infections, certain protozoan infections) and in such instances usually are not active in vivo.
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