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clearance

Pronunciation: kler'ants

Definition:

  1. Removal of a substance from the blood, by renal excretion, expressed in terms of the volume flow of arterial blood or plasma that would contain the amount of substance removed per unit of time; measured in mL/min. Renal clearance of any substance except urea or free water is calculated as the urine flow in mL/min multiplied by the urinary concentration of the substance divided by the arterial plasma concentration of the substance; normal human values are commonly expressed per 1.73 m2 body surface area.
  2. A condition in which bodies may pass each other without hindrance, or the distance between bodies.
  3. Removal of something from some place; esophageal acid clearance refers to removal from the esophagus of some acid that has refluxed into it from the stomach, evaluated by the time taken for restoration of a normal pH in the esophagus.
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© Copyright 2017 Wolters Kluwer. All Rights Reserved. Review Date: Sep 19, 2016.
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