- a cell in which the cytoplasm appears empty with the light microscope, as occurs in certain secretory cells of eccrine sweat glands and in the parathyroid glands when the glycogen is unstained;
- any cell, particularly a neoplastic one, containing abundant glycogen or other material that is not stained by hematoxylin or eosin, so that the cell cytoplasm is very pale in routinely stained sections.
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