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clamp-loader

Pronunciation: klamp lod'er

Definition: A multiprotein complex that catalyzes the assembly of circular sliding clamps on DNA to enable processive DNA replication. The complex binds primer template DNA and positions it in the center of a clamp to form a topologic link between the two.

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© Copyright 2018 Wolters Kluwer. All Rights Reserved. Review date: Sep 19, 2016.

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