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Pronunciation: kro'ma-tol'i-sis

Definition: The disintegration of the granules of chromophil substance (Nissl bodies) in a nerve cell body that may occur after exhaustion of the cell or damage to its peripheral process; other changes considered part of chromatolysis include swelling of the perikaryon and shifting of the nucleus from its central position to the periphery.

Synonym(s): chromatinolysis, chromolysis, tigrolysis

[chromato- + G. lysis, dissolution]

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