Definition: a transmembrane protein found on monocytes, macrophages, neutrophils, some B cells, and dendritic cells that is involved in signal transduction leading to oxidative burst and/or synthesis of tumor necrosis factor-a; expressed in some patients with acute nonlymphocytic leukemia and in B-cell chronic lymphocytic leukemia.
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Examples: glitazone, GI cocktail, etc.
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