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canine adenovirus 1


Definition: a virus causing infectious canine hepatitis in dogs. Targets hepatic and ocular cells; causes hepatitis and transient blue eye due to anterior uveitis and corneal edema that sometimes progresses to glaucoma. Intranucleal inclusion bodies develop in hepatocytes. Signs include pyrexia, vomition, leukopenia, anorexia, and painful abdomen. Direct transmission is through infected secretions such as urine. Many infections asymptomatic; not considered a zoonosis.

Synonym(s): Rubarth disease virus

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© Copyright 2018 Wolters Kluwer. All Rights Reserved. Review Date: Sep 19, 2016.