Skip to Content


Pronunciation: kal-mod′ū-lin

Definition: A small, ubiquitous eukaryotic protein that binds calcium ions, thereby becoming the agent for many of the cellular effects long ascribed to calcium ions. This calcium-protein complex binds to the apoenzyme, to form the holoenzyme, of certain phosphodiesterases; through these mechanisms, the complex regulates adenylate and guanylate cyclases, many kinases, phospholipase A2 activity, and other basic cellular functions.

[calcium + modulate]

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

© Copyright 2018 Wolters Kluwer. All Rights Reserved. Review date: Sep 19, 2016.