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cachectin

Pronunciation: ka-kek′tin

Definition: A polypeptide cytokine, produced by endotoxin-activated macrophages, which has the ability to modulate adipocyte metabolism, lyse tumor cells in vitro, and induce hemorrhagic necrosis of certain transplantable tumors in vivo.

Synonym(s): tumor necrosis factor

[G. kakos, bad, + hexis, condition of body]

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© Copyright 2017 Wolters Kluwer. All Rights Reserved. Review Date: Sep 19, 2016.
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