Definition: a form of malignant lymphoma reported in African children, frequently involving the jaw and abdominal lymph nodes. Geographic distribution of Burkitt lymphoma suggests that it is found in areas with endemic malaria. It is primarily a B-cell neoplasm and is believed to be caused by Epstein-Barr virus, a member of the family Herpesviridae, which can be isolated from tumor cells in culture; occasional cases of lymphoma with similar features have been reported in the U.S.
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