Definition: a pathologic entity, localized or generalized, characterized by an increase in bulk of brain tissue, due to expansion of the intravascular (congestion) or extravascular (edema) compartments that may coexist or may occur separately and be clinically indistinguishable; clinical manifestations depend on disturbed neuronal function due to local swelling, shifting of intracranial structures, and the effects of intracranial hypertension or circulatory disturbance.
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