Definition: an equation to calculate the respiratory dead space from the fact that gas expired from the lungs is a mixture of gas from the dead space and gas from the alveoli, the dead space volume divided by the tidal volume equals the difference between alveolar and mixed expired gas composition, divided by the difference between alveolar and inspired gas composition; gas composition can be expressed in any consistent units of concentration or partial pressure of oxygen or carbon dioxide.
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Examples: glitazone, GI cocktail, etc.