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big ACTH


Definition: a form of poorly processed ACTH produced by certain tumors, which is a larger and more acidic peptide molecule than little ACTH, but is not immunochemically distinguishable from it and does not exert any of the biologic effects characteristic of ACTH proteolytic digestion of big ACTH yields hormonally active little ACTH.

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© Copyright 2018 Wolters Kluwer. All Rights Reserved. Review date: Sep 19, 2016.