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Definition: A protein that marks germinal center-cell differentiation and regulates lymphocyte differentiation and immune response. Bcl-6 gene rearrangements and Bcl-6 protein expression are frequent in nodular lymphocyte-predominant Hodgkin lymphoma and suggest a germinal center–derived B-cell origin for Barrett esophagitis.

See Also: Barrett epithelium, Barrett syndrome

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© Copyright 2018 Wolters Kluwer. All Rights Reserved. Review Date: Sep 19, 2016.