- a diet having a caloric value equal to the basal heat production and sufficient quantities of essential nutrients to meet basic needs;
- in experiments in nutrition, a diet complete and adequate except for a single constituent (a vitamin, mineral, or amino acid), the nutritional value of which is to be determined, is omitted for a period and the effects observed; the subject is observed for a second period during which the ingredient being studied is added to the diet.
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Examples: glitazone, GI cocktail, etc.