Skip to Content
Medical Term:

Bartter syndrome

Pronunciation: bar'ter


a renal disorder due to a defect in active chloride reabsorption in the loop of Henle; characterized by primary juxtaglomerular cell hyperplasia with secondary hyperaldosteronism, hypokalemic alkalosis, hypercalciuria, elevated renin or angiotensin levels, normal or low blood pressure, and growth retardation; edema is absent. Autosomal recessive inheritance, caused by mutation in either the Na-K-2Cl cotransporter gene (SLC12A1) on chromosome 15q or the K(+) channel gene (KCNJ1) on 11q.

© Copyright 2017 Wolters Kluwer. All Rights Reserved. Review Date: Sep 19, 2016.