autoimmune hemolytic anemia
- cold-antibody type, caused by hemagglutinating antibody (usually IgM class) maximally active at 4°C and resulting from severe hemolysis in cold hemagglutinin disease;
- warm-antibody type (the most common), acquired hemolytic anemia attributable to a reaction between the patient's red blood cells and serum autoantibodies (usually IgG class), maximally active at 37°C; it varies in severity, occurs in all age groups of both sexes, and may be idiopathic or secondary to neoplastic, autoimmune, or other disease.
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