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atropine

Pronunciation: at′rō-pēn

Definition: A racemic mixture of d- and l- hyoscyamine, alkaloids obtained from the leaves and roots of Atropa belladonna; an anticholinergic, with diverse effects (tachycardia, mydriasis, cycloplegia, constipation, urinary retention, antisudorific) attributable to reversible competitive blockade of acetylcholine at muscarinic type cholinergic receptors; most commonly used in the treatment of poisoning with organophosphate insecticides or nerve gases, as well as certain types of bradydysrhythmias and to prevent secretions during preparation for general anesthesia. The (–) form is by far the more active.

Synonym(s): dl-hyoscyamine, tropine tropate

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© Copyright 2017 Wolters Kluwer. All Rights Reserved. Review Date: Sep 19, 2016.
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