atrial natriuretic peptide
a 28–amino acid peptide (a-ANP) derived from cardiac atria, several smaller fragments of a-ANP, and a dimer of a-ANP with 56 amino acids (ß-ANP) that are present in plasma in heart failure. Among other actions, ANP promotes renal salt and water excretion, increases capillary function, and decreases arterial pressure and the secretion of renin, angiotensin, aldosterone, and antidiuretic hormone.
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Examples: glitazone, GI cocktail, etc.