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Medical Term:

asparagine ligase


an acid:ammonia ligase (amide synthetase) forming l-asparagine and l-glutamate from l-aspartate and l-glutamine, with the concomitant cleavage of ATP to AMP and pyrophosphate. Under nonphysiological conditions, the mammalian enzyme can use ammonia as the nitrogen donor. Asparagine ligase also displays a glutaminase-like activity.

Synonym(s): asparagine synthetase

© Copyright 2017 Wolters Kluwer. All Rights Reserved. Review Date: Sep 19, 2016.