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aristolochic acids

Pronunciation: ă′ris-tō-lō′kik as′idz

Definition: Aromatic mixtures of nitrophenanthrene derivatives from plants of the genus Aristolochia. Some are components of various Chinese herbal medications, known to cause interstitial renal fibrosis that can progress to end-stage renal disease (ESRD) even after discontinuation of intake. Some are potent carcinogens, employed in animal and bacterial studies. Human urothelial carcinomas can result from their use.

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© Copyright 2017 Wolters Kluwer. All Rights Reserved. Review Date: Sep 19, 2016.
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