an apolipoprotein found in several plasma lipoprotein particles including chylomicrons, VLDL, and HDL. Three major isoforms are encoded by three common alleles at the Apo E locus: E2, E2, and E4. The E2 allele is associated with lower total plasma cholesterol and LDL cholesterol than is E3, whereas E4 is associated with higher LDL and total cholesterol than E3.
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Examples: glitazone, GI cocktail, etc.