antineutrophil cytoplasmic antibodies
Definition: autoantibodies found in some autoimmune diseases, recognized by their reactivity with cytoplasmic antigens in neutrophils; two groups are recognized: c-ANCA, reacting with proteinase 3, is found in polyangiitis and Churg-Strauss syndrome; p-ANCA, reacting with myeloperoxidase is found in Wegener granulomatosis.
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