Skip to Content

anticipation

Pronunciation: an-tis′i-pā′shŭn

Definition:

  1. Appearance before the appointed time of a periodic symptom or sign.
  2. Progressively earlier age of manifestation of a hereditary disease in successive generations; may be factitious (because of heightened awareness of early signs of the disease or because these signs are more conspicuous in the young) or authentic (because of progressive loss of epistatic and modifier genes by recombination and segregation, or because of expansion of unstable alleles in successive generations).
  3. An increase in the severity of a phenotype in successive generations of a family, often associated with an increase in the number of trinucleotide repeats in a causative gene (e.g., fragile X syndrome, myotonic dystrophy, Huntington disease).
Disclaimer: This site is designed to offer information for general educational purposes only. The health information furnished on this site and the interactive responses are not intended to be professional advice and are not intended to replace personal consultation with a qualified physician, pharmacist, or other healthcare professional. You must always seek the advice of a professional for questions related to a disease, disease symptoms, and appropriate therapeutic treatments.
© Copyright 2017 Wolters Kluwer. All Rights Reserved. Review Date: Sep 19, 2016.
Hide