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anthrax lethal factor

Pronunciation: an′thraks lē′thăl fak′tŏr

Definition: A protein secreted by Bacillus anthracis, that selectively induces apoptosis of activated macrophages by cleaving the amino-terminal extension of mitogen-activated protein kinase kinases (MKKs). This action may allow the bacteria to avoid detection by the host's innate immune system.

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© Copyright 2018 Wolters Kluwer. All Rights Reserved. Review Date: Sep 19, 2016.