anterior chamber cleavage syndrome
a congenital disorder originating from faulty separation of embryonic structures; it results in bilateral central corneal opacities, with an anterior ring attachment of the iridic pupillary border and anterior polar cataracts; associated with short-limbed dwarfism; these are autosomal dominant and autosomal recessive forms, caused by mutation in the PAX6 gene, the PITX2 gene, the CYP1B1, or the FOXC1 gene.
Synonym(s): Peters anomaly
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