Definition: Loss or absence of the sense of smell. It may be: general to all odorants (total), partial to some odorants, or specific to one or more odorants; due to transport disorders (in nasal obstruction) or sensorineural disorders (affecting the olfactory neuroepithelium or the central olfactory neural pathways); or hereditary or acquired. Recent studies indicate it is often the first sensory loss directly related to Alzheimer disease.
[G. an- priv. + osmē, sense of smell]
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