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angiotensin-converting enzyme

 

Definition: A zinc-containing hydrolase cleaving C-terminal dipeptides from a variety of substrates, including angiotensin I, which is converted to angiotensin II and histidylleucine (an important step in the metabolism of certain vasopressor agents). Drugs that inhibit it are used to treat hypertension and congestive heart failure.

Synonym(s): peptidyl dipeptidase A

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© Copyright 2017 Wolters Kluwer. All Rights Reserved. Review Date: Sep 19, 2016.
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