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anaplastic lymphoma kinase gene rearranged non-small-cell lung


Definition: A fusion protein resulting from the rearrangement of the EML4 gene with the ALK gene, present in approximately 5% of non-small-cell lung cancers, primarily adenocarcinomas. This fusion protein is a target of ALK tyrosine kinase inhibitors in the treatment of these tumors.

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© Copyright 2018 Wolters Kluwer. All Rights Reserved. Review date: Sep 19, 2016.