Definition: an enzyme (usually a pyridinoenzyme) that catalyzes the transfer of hydrogen from some metabolite to some acceptor molecule (NAD+, cytochrome) other than dioxygen; lactate dehydrogenases, isocitrate dehydrogenases, and others in EC class 1, excluding those listed under aerobic dehydrogenase.
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Examples: glitazone, GI cocktail, etc.