aminoadipic ΄-semialdehyde synthase
Pronunciation: ă-mē′nō-ă-dip′ik se′mē-al′di-hīd sin′thās
Definition: A bifunctional enzyme used in lysine degradation; it has a lysine:α-ketoglutarate reductase activity as well as a saccharopine dehydrogenase activity. A deficiency of this enzyme results in familial hyperlysinemia.
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Examples: glitazone, GI cocktail, etc.