Definition: the ratio of serum alanine aminotransferase to serum aspartate aminotransferase; elevated serum levels of both enzymes characterize hepatic disease; when both levels are abnormally elevated and the ALT:AST ratio is greater than 1.0, severe hepatic necrosis or alcoholic hepatic disease is likely; when the ratio is less than 1.0, an acute nonalcoholic hepatic condition is favored.
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Examples: glitazone, GI cocktail, etc.