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Definition: A metalloprotease; its function is to cleave large von Willebrand multimers. Inhibition of ADAMS13 is associated with the hematologic disease thrombotic thrombocytopenic purpura. The name ADAMS13 comes from a disintegrin and metalloproteinase with a thrombospondin type 1 motif, member 13.

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© Copyright 2017 Wolters Kluwer. All Rights Reserved. Review Date: Sep 19, 2016.