A metalloprotease; its function is to cleave large von Willebrand multimers. Inhibition of ADAMS13 is associated with the hematologic disease thrombotic thrombocytopenic purpura. The name ADAMS13 comes from a disintegrin and metalloproteinase with a thrombospondin type 1 motif, member 13.
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Examples: glitazone, GI cocktail, etc.