Definition: A “high-energy” bond formed by the condensation of a carboxyl group (—COOH) and a mercaptan (or thiol) group (—SH); widely formed in the course of intermediary metabolism, notably in the oxidation of fats, where the —SH is part of coenzyme A and the —COOH is part of the fatty acid being oxidized.
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Examples: glitazone, GI cocktail, etc.
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