acute chest syndrome
a syndrome occurring in association with sickle cell disease defined by a new infiltrate on chest radiograph; associated with one or more new symptoms: fever, cough, sputum production, dyspnea, or hypoxia. It occurs most commonly in the 2–4-year-old age group and declines in incidence with age. A past history of this finding is associated with earlier mortality compared with those patients who have never experienced an episode.
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Examples: glitazone, GI cocktail, etc.