In prostate cancer, a approach in which immediate therapy is postponed in patients at low risk for progression. Treatment of localized disease is initiated when the patient develops an increased risk of disease progression. This approach should not be confused with watchful waiting (q.v.), in which treatment of local disease is not performed based on the belief it would not be helpful due to the long natural course of the disease.
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Examples: glitazone, GI cocktail, etc.