Definition: a progressive hereditary defect of zinc metabolism in young children (onset, 3 weeks–18 months); often manifests first as a blistering, oozing, and crusting eruption on an extremity or around one of the orifices of the body, followed by loss of hair and by diarrhea or other gastrointestinal disturbances; relieved by lifelong oral zinc supplementation; autosomal recessive trait.
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Examples: glitazone, GI cocktail, etc.