Neonatal lethal dwarfism characterized by severe bone dysplasia of all four limbs, micromelia, enlarged cranium, and a short trunk with delayed or absent ossification of the lower spine and pubic bones. There are various types. See subentries to this term.
[G. a- priv. + chondros, cartilage, + genesis, origin]
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Examples: glitazone, GI cocktail, etc.