Definition: an enzyme catalyzing the thioclastic cleavage by coenzyme A of β-ketoacyl-CoA, forming an acyl-CoA with a carbon chain shorter by two atoms, the missing two atoms appearing as acetyl-CoA. A step in fatty acid degradation.
Synonym(s): 3-ketoacyl-CoA thiolase, β-ketothiolase
See Also: acetyl-CoA acetyltransferase
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Examples: glitazone, GI cocktail, etc.