Definition: Intermediate in the oxidation of fatty acids and in the formation of ketone bodies; also formed from two molecules of acetyl-CoA and in the degradation of ketogenic amino acids; major role is condensation with acetyl-CoA to form β-hydroxy-β-methylglutaryl-CoA.
Synonym(s): acetoacetyl-coenzyme A
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Examples: glitazone, GI cocktail, etc.